A Comparison of the Daily Infant Dietary Estrogenic Dose Associated With Ingestion Bisphenol-A vs. Naturally Occurring Compounds. B. Finley, M. Goodman, D. J. Cher, and K. Connor, Exponent, CA and MD
It has recently been suggested that potential migration of residual bisphenol-A (BPA) from polycarbonate baby bottles may pose an endocrine disruptive health threat to infants. Although high doses of BPA in animals can cause estrogenic effects, conflicting evidence exists as to whether such effects occur in animals at the much lower doses that might be experienced by bottle-fed infants. In order to accurately assess potential estrogenic risk to infants, it is important to account for the daily estrogenic dose associated with the presence of estrogen, progesterone, and other very potent "estrogen-like" compounds in breast milk, cow’s milk and other baby foods. In this paper, we present a comparative analysis of the daily infant estrogenic dose associated with the presence of BPA in consumed liquids vs. the dose associated with the consumption of naturally occurring estrogenic compounds in baby foods. Data from recent extraction studies conducted with polycarbonate bottles and published estimates of the volume and composition of the daily infant diet were used to derive plausible estimates of daily doses of BPA and naturally occurring estrogenic compounds for a variety of ethnic and socioeconomic groups. These doses were then normalized to "estrogenic equivalent" doses using published estimates of the relative estrogenic potency of BPA and the naturally occurring compounds. Our findings indicate that the even the maximally plausible estrogenic dose of BPA that might be experienced by an infant is orders of magnitude below the total estrogenic dose associated with naturally occurring compounds. Accordingly, we conclude that migration of BPA from polycarbonate bottles poses no endocrine disruptive health risk to infants.
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