A Consumer’s Guide to Benchmark Dose Models; Results of EPA QA/QC Testing. J. S. Gift, T. A. Dawson, J. Caldwell, and R. W. Setzer, US EPA, NCEPA/NHEERL, RTP, NC
Benchmark dose risk assessment software (BMDS) was designed by EPA to generate dose-response curves and facilitate the analysis, interpretation and synthesis of toxicological data. BMDS provides a Windows 95/98 interface to run seven (7) models (Gamma, Logistic/Log-Logistic, Multistage, Probit/Log-Probit, Quantal-Linear, Quantal-Quadratic, and Weibull) that are appropriate for the analysis of dichotomous data, four (4) models (Linear/Polynomial, Power, Hill and Hybrid) for continuous dose response data and three (3) nested developmental toxicology data (NLogistic, NCTR, and Rai & Van Ryzin). Partial results of QA/QC testing of the EPA BMDS are presented. One part of EPA QA/QC testing of the BMDS performed during the summer of 1999 involved comparing the BMDS models to other, correlate models developed outside of EPA. Each of the EPA and non-EPA models were applied to 100 dichotomous or continuous dose-response data sets appropriate for evaluation by the model. Data sets were obtained primarily from cancer and non-cancer summaries in the EPA’s Integrated Risk Information System (IRIS) database. Textual and graphical results of the model runs (e.g., maximum likelihood values for the fitted model and p-values, shape of the fitted curve) are presented and evaluated for the purpose of determining the strengths and weaknesses of each model.
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