Comparison of External Dose With Internal Dose of Inorganic Arsenic Using PB-PK Model. H. Lee, S. Choi, E. Yoon, and K. Kim, Korea Food and Drug Adminstration, Nokbun-dong, Eunpyung-ku, Seoul, Korea; and D. Yu, Korea Atomic Energy Research Institute, Yusong, Daejon, Korea
Everyone is exposed to arsenic (especially organic arsenic) because very low levels of it are always present in soil, water, food and air. For most people, food constitutes the largest source of arsenic intake (about 25 to 50งถ/day). Organic arsenic often occurs naturally in seafood such as shrimp and inorganic arsenic may also occur in foods and animal feeds as a result of pesticide application. Exposure to high levels of inorganic arsenic can cause vomiting, diarrhea, blood vessel change, or death in extreme cases. Inorganic arsenic is classified as group A (human carcinogen) from IRIS (U.S.EPA, 1999) based on sufficient evidence from the increase in human lung cancer through inhalation and increased incidence of skin cancer through drinking water. This study was conducted to compare the difference of external dose with internal dose by using PB-PK model. For the quantification of external dose, it was applied by exposure parameter such as arsenic concentration of laver, adult body weight (61kg) and consumption rate (2.3g/day). For the operation of PB-PK model, it employed various parameter such as tissue/blood partition coefficients, tissue volume, blood flow rate and so on. The result of this study can be used for uncertainty analysis of risk assessment based on external dose.
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