FQPA: The Need to Expand Approaches for Estimating Dietary Exposure to Contaminants in Meat and Milk. A. E. Love, L. M. Barraj, C. L. Walls, and B. M. Polakoff, Novigen Sciences, Inc., Washington DC
Residues in meats and milk are determined, in part, by the feeds that are included in the animals’ diets, as well as by the contribution of each of these feeds to the total ration, and contaminant residue levels in these feeds. The method currently used by EPA assumes a worst-case diet, which includes maximum residue levels and is only applicable to individual compounds. However, not only is it possible that a given feed may have been treated with more than one compound, but typical animal diets include a mixture of feeds, each with its own treatment history. Thus, the animal diets may result in edible animal tissues and milk potentially containing more than one contaminant. The Food Quality Protection Act of 1996 (FQPA) requires that cumulative exposures to chemicals that have a "common mechanism of toxicity" be considered. We propose expanding a previously developed Monte Carlo approach (SRA, 1997) for estimating potential residues in animal diets, to allow for the estimation of multiple compound residues in milk and edible animal tissues. The proposed approach uses Monte Carlo methods to determine which feed items are included in the animal diets and which compound or combination of compounds may be present in these feeds and at what levels. The approach also allows for the use of several methods to adjust for the different potencies of the various compounds.
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