Validation of Bioassays for Reproductive Toxicity. W. A. Price and G. B. Briggs, GEO Centers Inc., Naval Health Research Center, WPAFB, OH; W. K. Alexander and K. R. Still, Naval Health Research Center, WPAFB, OH; and K. Grassman, Wright State University, Department of Biological Sciences
Validation of new bioassay methods for evaluating reproductive toxicity is essential to quantitative risk analysis. The Naval Health Research Center, Toxicology Detachment is conducting toxicity studies in laboratory animals that provide data for risk assessment and management. The conventional research method for evaluating male reproductive risk to Navy personnel is to expose laboratory animals to chemicals that may produce a hazard in Navy operations. New methods for evaluating reproductive toxicity are under development and validation that are more robust, predictive, less prone to bias and much faster. The results of the validation process for evaluating sperm quality in laboratory animals by using a fluoroscene dye staining procedure and the sperm analyzer to produce computer assisted semen analysis (CASA) data are presented. A positive chemical agent for testicular damage (methoxyacetic acid) was dosed to rats and compared with histological evidence of damage and also compared with results of testicular damage studies using flow cytometry.
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