Comparative Risk, Children’s Health, and Multiple Chemical Exposures. C. Stroebel, A. Kukowski, and P. Shubat, Minnesota Department of Health, St. Paul, MN
Comparative risk may be used as a tool to help decision-makers better understand health risks and set policy priorities for environmental health hazards. Using data collected during the Minnesota Children’s Pesticide Exposure Study, the Minnesota Department of Health compared children’s health risks from exposures to multiple chemicals, including pesticides, volatile organic chemicals, metals, and polyaromatic hydrocarbons. Samples were analyzed for air (indoor, outdoor, personal), water, soil, house dust, food, beverages, blood, urine, and hair. In addition, questionnaire data were used to estimate body weight, water intake, and time-activity patterns. Average daily doses were calculated using exposure assumptions from the U.S. EPA Exposure Factors Handbook and measurements of chemicals in 102 households with children. Aggregate exposures were calculated for chemicals with common health endpoints, and these exposures were compared to toxicity values (e.g. reference dose, cancer unit risk) derived from the U.S. EPA Integrated Risk Information System (IRIS), and other sources, where appropriate. Toxicity values were selected for the most sensitive health endpoint based on a chemical-by-chemical evaluation of the toxicological data. Results will compare children’s health risks for exposures to multiple chemicals, and will identify data gaps and uncertainties in the risk analysis.
Work supported by LCMR. Data collected in collaboration with the U.S. EPA, UMN, RTI, and EOHSI.
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