Multimedia Exposure Assessment: Relationship Between Household Dust Measurements and Serum Pesticide Concentrations: Results from Nhexas-Maryland. B. Ryan, A. Thompsen, J. Hoppin, J. Brock, and D. MacIntosh, Emory University
Assessment of exposure to environmental contaminants is often effected through the measurements of contaminating species in specific environments thought to influence such exposure. Alternative methods invoke biological markers of exposure that use easily-collected biological media, such as blood or urine. Such markers are typically the parent compound or a direct metabolite of the compound of interest. Persistent chlorinated pesticides represent a class of contaminants of interest to risk assessors and health professionals alike because of their carcinogenic potential as well as their ubiquity in the environment. It has been established that the primary pathways of exposure to these species is through inadvertent ingestion and inhalation of contaminated house dust and soil. In this work, we report environmental concentrations of selected organochlorine pesticides in house dust and soil in conjunction with serum pesticide concentration in volunteers living in the same homes. Data were collected from approximately 80 individuals living in Baltimore and four surrounding counties during six monitoring period spread throughout the year as part of the NHEXAS-Maryland investigations. We report separately the results the biological and environmental measures including the assessment of temporal variability in the observed measurements. Further, we report results of modeling the biological measure of exposure using house dust and soil concentrations in an effort to determine whether these factors are valid predictors of the biological levels observed The results suggest the relationships between environmental measures of exposure and biomarkers of exposure that are of interest to the risk assessment community.
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