A Comparison of Human Health Risk Values Derived by Different Organizations for 20 Priority Hazardous Substances and for Chemicals in the International Toxicity Estimates for Risk (ITER) Database. A. Wullenweber, S. Lawson, and A. Maier, Toxicology Excellence for Risk Assessment (TERA)
Human health risk values are used by many organizations to make important public health decisions, and are developed by various organizations from around the world. Not all organizations derive risk values for the same chemicals, and even if they do, the values may differ due to scientific judgments, the mission of the organization, or the use of more recently published data. This analysis identifies risk values derived by the Agency for Toxic Substances and Disease Registry, Health Canada, the National Institute of Public Health and the Environment (The Netherlands), U.S. Environmental Protection Agency, and independent parties. This comprehensive study stems from an earlier, more preliminary, evaluation and identifies the availability of data from each organization for 20 Priority Hazardous Substances and for all chemicals in the International Toxicity Estimates for Risk (ITER) database. It also identifies the number of chemicals in ITER with data from only one organization as well as the number of chemicals with data from more than one organization. This study illustrates the availability (or lack thereof) of risk values for different chemicals from a variety of organizations, and the importance of being able to evaluate all available risk values before making public health decisions.
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