International Toxicity Estimates for Risk Database Now Includes CIIT Formaldehyde Cancer Risk Data

RiskWorld contact Mary Bryant, associate editor
November 15, 2001 -- Toxicology Excellence for Risk Assessment (TERA) recently added formaldehyde cancer risk data from the Chemical Industry Institute of Toxicology (CIIT) to TERA's International Toxicity Estimates for Risk (ITER) database. The CIIT data for the carcinogenic risk from inhaled formaldehyde is listed under the ITER column at http://iter.ctcnet.net/publicurl/pub_view_list.cfm?crn=50%2D00%2D0.

The CIIT assessment integrated site-specific modeling of dose of formaldehyde delivered to the upper respiratory tracts of animals and humans with a biologically based two-stage clonal growth model of carcinogenesis. The two-stage clonal growth model incorporates data on the rate of cell division and on the number of cells at risk in different regions of the respiratory tract of rats and humans. The model was used to estimate cancer risk for exposure to varying levels of formaldehyde for workplace and environmental exposure scenarios.

An external peer review panel of international scientists approved this assessment during a workshop convened by Health Canada and U.S. EPA; however, this assessment does not represent the cancer risk assessments for formaldehyde of Health Canada or U.S. EPA. The CIIT assessment has been included here to provide ITER users access to this important new model of formaldehyde cancer risk.

ITER is a free Internet database of human health risk values for over 500 chemicals of environmental concern from several organizations worldwide. ITER is the only database that provides this data in a table format that allows side-by-side comparisons of risk values from different organizations. For more information or for a list of recent additions or updates to ITER, see www.tera.org/iter/.

Contact: Andrea Wullenweber, wullenweber@tera.org

Announcement (previously published in RiskWorld's homepage)

TERA Hires Visiting Scientists. Daniel Briggs and P. J. (Bert) Hakkinen have recently joined Toxicology Excellence for Risk Assessment (TERA) as visiting scientists who will contribute to several TERA projects, including its new Peer Consultation Program. TERA is a non-profit corporation dedicated to the best use of toxicity data for risk assessment. More information is available at http://www.tera.org/news/visiting%20scientist%20ann.htm. (Posted 11/15/01.)

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