Dermal Absorption from Environmental Matrices: Attention to Fundamental Concepts. J. C. Kissel and A. L. Bunge, University of Washington, Colorado School of Mines
Beginning in the late 1970ís Mackay and co-workers popularized a systematic approach to description of the environmental behavior of chemical contaminants that they dubbed the Fugacity Approach. The underlying concepts involved were not original, but the organization of those concepts and terminology used proved helpful to many students and practitioners of environmental science and engineering. The Fugacity Approach is logically and readily adapted to investigation of the availability of environmental contaminants to humans and other organisms in the context of risk assessment. Indeed, several research groups have explicitly employed Mackayís terminology in proposing models of dermal absorption. Nevertheless, the utility of the fundamental concepts underlying the Fugacity Approach is apparently not universally recognized. A recent review of dermal absorption from soil, for instance, describes the dermal bioavailability of several lipophilic compounds as "the same [from] soil and solvent." We use the concepts of the Fugacity Approach and recent empirical findings that support it to analyze the results noted above and results from other experiments. Insights gained should be useful to both dermal pathway investigators and members of the broader risk assessment community who deal with availability issues.
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